Pharmacological properties Tazorac Cream:
Tazorac Cream As with other retinoids tazaroten binds to specific receptors, affects the differentiation, proliferation of keratinocytes and has anti-inflammatory action. Tazaroten effective in psoriasis. Tazaroten has low toxicity, which is due to its low absorption, rapid metabolism to the formation of hydrophilic compounds do not accumulate in fat tissue. The skin becomes tazaroten tazarotenovuyu acid, which is further metabolised and rapidly excreted through the urinary tract and intestines. The half-life of about 18 h.
Application Tazorac Cream:
The gel is applied once a day at the lesion with mild forms of psoriasis. Application tazarotena provides clinical benefit after the first week of treatment. The result of treatment persists up to 12 weeks after cessation of treatment. Efficiency comparable to that achieved tazarotena with strong corticosteroid creams containing 0.05% fluotsinonida.
Side effects Tazorac Cream:
The most common side effects (itching, burning and erythema) developed in nearly all patients. In combination with a corticosteroid ointment, these phenomena are smoothed out somewhat. Note that this combination also reduces the possibility of steroid atrophy of the skin.
Interactions Tazorac Cream:
Ddya reduce these side effects developed a method of short-term application tazarotena the skin with a combination of calcipotriol (vitamin D 3 dayvoneksom). Tazaroten proved effective in combination with ultraviolet irradiation. The radiation dose and treatment time decreases.
